10 Oct 2026MicrobiologyParasitology
A 28-year-old man returning from a 2-week trip to sub-Saharan Africa is brought to the emergency department with high-grade fever, severe headache, and progressive drowsiness. On examination his GCS is 11/15, he is haemodynamically unstable, and he cannot tolerate oral intake. A peripheral blood smear demonstrates numerous ring-form trophozoites and occasional banana-shaped gametocytes consistent with Plasmodium falciparum, with a parasitaemia of >5 %. Given the suspected chloroquine-resistant strain and severity, which of the following is the most appropriate first-line therapy?
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