An adolescent boy is investigated for recurrent unilateral epistaxis and nasal obstruction, and a vascular nasopharyngeal mass is found. Biopsy is strongly discouraged because it can provoke torrential haemorrhage. The best explanation for this bleeding tendency is:
- A.Erodes internal carotid artery
- B.Vessels lack a muscle coat
- C.Releases a fibrinolytic factor
- D.Tumour lacks a capsule
Show answer and explanation
Answer: B. Vessels lack a muscle coat
Correct answer: B. Vessels lack a muscle coat.
Juvenile nasopharyngeal angiofibroma is a fibrovascular tumour in which the vessels are irregular, thin-walled channels lined only by endothelium and lacking a complete smooth-muscle media. Because these vessels cannot contract when cut, biopsy produces torrential bleeding, so diagnosis relies on contrast imaging and angiography rather than tissue sampling.
Fibrous stroma with thin-walled, muscle-poor vessels of angiofibroma.
Incorrect Options:
- A. Erodes internal carotid artery: advanced tumour may reach the skull base, but routine biopsy bleeding is from its own defective vessels, not carotid erosion.
Angiography of the internal carotid artery. - C. Releases a fibrinolytic factor: the tumour does not secrete a fibrinolysin; bleeding is structural, not a clotting defect.
Fibrin strands enmeshing red cells (a fibrinolysin would dissolve these). - D. Tumour lacks a capsule: the angiofibroma is indeed unencapsulated, but absence of a capsule does not by itself cause bleeding.
A well-circumscribed encapsulated tumour, shown for contrast.
High-Yield Facts:
- Classic patient: adolescent male with recurrent epistaxis and nasal obstruction.
- Holman-Miller sign (anterior bowing of the posterior maxillary wall) on imaging.
- Diagnosis by contrast imaging and angiography; biopsy is contraindicated.
- Treatment: pre-operative embolisation then surgical excision.




Auditory evoked-potential waveform (SP/AP peaks against latency) - a screening electrophysiology test.
Axial HRCT temporal bone (bone window) - shows osseous anatomy, not the soft-tissue tumour.
Tympanogram (admittance vs pressure) - a middle-ear test, unaffected by a retrocochlear tumour.