During autopsy of a young farmer, 5 mL of gastric aspirate is diluted with 15 mL of water in a flask. A strip of filter paper soaked in 0.1 percent silver nitrate is suspended over the mouth of the flask, which is then gently warmed. The paper turns black. Which poison does this bedside test indicate?
- A.Paraquat
- B.Arsenic poisoning
- C.Organophosphate insecticide
- D.Aluminium phosphide
Show answer and explanation
Answer: D. Aluminium phosphide
Correct answer: D. Aluminium phosphide.
Why this is correct: Aluminium phosphide (celphos, a grain fumigant) reacts with moisture and gastric acid to liberate phosphine gas. On warming the aspirate, phosphine rises and reduces silver nitrate to metallic silver, turning the impregnated paper black (the silver nitrate paper test). Phosphine causes profound cardiotoxicity, refractory shock and metabolic acidosis; there is no specific antidote, so management is supportive, sometimes with magnesium sulphate and intensive haemodynamic support.
Aluminium phosphide tablets - release phosphine that blackens silver nitrate paper.
Incorrect Options:
- A. Paraquat: A herbicide causing progressive pulmonary fibrosis; it does not release phosphine or blacken silver nitrate paper.
- B. Arsenic poisoning: Detected by the Reinsch or Marsh test (silver-grey mirror), not by phosphine liberation.
- C. Organophosphate insecticide: Causes a cholinergic crisis with low pseudocholinesterase; the antidote is atropine plus pralidoxime, and it does not blacken silver nitrate paper.
Paraquat, a lung-toxic herbicide.
Arsenic - identified by the Marsh/Reinsch test.
An organophosphate (malathion) - treated with atropine and pralidoxime.
High-Yield Facts:
- Aluminium phosphide releases phosphine, which reduces silver nitrate paper to black metallic silver.
- There is no antidote; care is supportive, with magnesium sulphate and aggressive shock management.
- Arsenic is detected by the Marsh and Reinsch tests; organophosphates by low cholinesterase.
- Phosphine has a garlic or decaying-fish odour and causes severe cardiotoxic shock.